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Case Reports
, 372 (25), 2423-7

Persistence of Ebola Virus in Ocular Fluid During Convalescence

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Case Reports

Persistence of Ebola Virus in Ocular Fluid During Convalescence

Jay B Varkey et al. N Engl J Med.

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Abstract

Among the survivors of Ebola virus disease (EVD), complications that include uveitis can develop during convalescence, although the incidence and pathogenesis of EVD-associated uveitis are unknown. We describe a patient who recovered from EVD and was subsequently found to have severe unilateral uveitis during convalescence. Viable Zaire ebolavirus (EBOV) was detected in aqueous humor 14 weeks after the onset of EVD and 9 weeks after the clearance of viremia.

Figures

Figure 1
Figure 1. Montage Fundus Photographs 10 Weeks after the Onset of Ebola Virus Disease
Multiple peripheral chorioretinal scars with hypopigmented haloes are visible in the right eye (Panel A) and left eye (Panel B) (white arrows). A small intraretinal hemorrhage (black arrow) is adjacent to a chorioretinal scar in the left eye.
Figure 2
Figure 2. Slit-Lamp Photograph of the Left Eye 14 Weeks after the Onset of Ebola Virus Disease
Mild corneal edema, rare keratic precipitates (arrows), and inflammatory cells and protein in the anterior chamber are consistent with acute anterior uveitis.
Figure 3
Figure 3. Fundus Photograph of the Left Eye 14 Weeks after the Onset of Ebola Virus Disease
Severe vitritis is indicated by the obscuration of the optic nerve and blood vessels.

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