Persistence of Ebola Virus in Ocular Fluid during Convalescence

N Engl J Med. 2015 Jun 18;372(25):2423-7. doi: 10.1056/NEJMoa1500306. Epub 2015 May 7.


Among the survivors of Ebola virus disease (EVD), complications that include uveitis can develop during convalescence, although the incidence and pathogenesis of EVD-associated uveitis are unknown. We describe a patient who recovered from EVD and was subsequently found to have severe unilateral uveitis during convalescence. Viable Zaire ebolavirus (EBOV) was detected in aqueous humor 14 weeks after the onset of EVD and 9 weeks after the clearance of viremia.

Publication types

  • Case Reports
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aqueous Humor / virology*
  • Convalescence
  • Ebolavirus / isolation & purification*
  • Fundus Oculi
  • Hemorrhagic Fever, Ebola / complications*
  • Humans
  • Male
  • Panuveitis / virology*
  • Vision Disorders / virology*