Small molecule binding to a G-hairpin and a G-triplex: a new insight into anticancer drug design targeting G-rich regions

Chem Commun (Camb). 2015 Jun 4;51(44):9181-4. doi: 10.1039/c5cc01678a.

Abstract

To gain new insights into G-quadruplex-drug interactions, we captured the solution-state structures of the complexes between a drug-like small molecule and a G-hairpin/G-triplex. Our results indicated that the ligand initially binds to the intermediates and induces stepwise folding into a quadruplex.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemistry*
  • Biotin / chemistry*
  • DNA / chemistry*
  • Drug Design
  • Guanine / chemistry*
  • Nucleic Acid Conformation
  • Pyridines / chemistry*

Substances

  • Antineoplastic Agents
  • Pyridines
  • Guanine
  • Biotin
  • DNA