Prevalence of glucose intolerance at 6 weeks postpartum in Indian women with gestational diabetes mellitus

Diabetes Metab Syndr. Jul-Sep 2015;9(3):143-6. doi: 10.1016/j.dsx.2015.04.016. Epub 2015 Apr 25.

Abstract

Aims: Women with a history of gestational diabetes mellitus (GDM) have an increased risk for future glucose intolerance, and should be followed up with subsequent screening for the development of diabetes or pre-diabetes at 6-12 weeks postpartum. We studied the prevalence of glucose intolerance at 6 weeks postpartum in Indian women with GDM diagnosed according to ADA criteria.

Materials and methods: This longitudinal study, conducted at a tertiary care centre, included 75 Asian-Indian women aged ≥18 years, with a diagnosis of GDM (as per ADA criteria), who were referred to the Endocrine Department at Indraprastha Apollo Hospital, Delhi. A 2-h 75 g oral glucose tolerance test (OGTT) was performed at 6 weeks postpartum.

Results: Out of the 75 women who had GDM and were recommended an OGTT at 6 weeks postpartum, 17.3% did not return for the test. Out of 62 women, one-third (33.8%) developed an abnormal OGTT at 6 weeks postpartum, while 66.1% had reverted to normal glucose tolerance. Impaired fasting glucose (IFG) was seen in 14.5%, 4.8% had impaired glucose tolerance (IGT), 8% had both IFG and IGT, and 6.4% had overt type 2 diabetes.

Conclusion: Our study emphasizes the need for compulsory follow up OGTT for women with GDM in our part of the world in view of ethnicity and prevailing socio-cultural factors.

Keywords: Gestational diabetes; Postpartum; Type 2 diabetes.

MeSH terms

  • Adult
  • Diabetes Mellitus, Type 2 / epidemiology
  • Diabetes, Gestational*
  • Female
  • Glucose Intolerance / epidemiology*
  • Glucose Tolerance Test
  • Humans
  • India
  • Longitudinal Studies
  • Postpartum Period*
  • Pregnancy
  • Risk Factors
  • Socioeconomic Factors