Complete Closed Genome Sequences of a Mannheimia haemolytica Serotype A1 Leukotoxin Deletion Mutant and Its Wild-Type Parent Strain

Michael P Heaton; Gregory P Harhay; Timothy P L Smith; James L Bono; Carol G Chitko-McKown

doi:10.1128/genomeA.00417-15

Complete Closed Genome Sequences of a Mannheimia haemolytica Serotype A1 Leukotoxin Deletion Mutant and Its Wild-Type Parent Strain

Genome Announc. 2015 May 7;3(3):e00417-15. doi: 10.1128/genomeA.00417-15.

Authors

Michael P Heaton¹, Gregory P Harhay², Timothy P L Smith², James L Bono², Carol G Chitko-McKown²

Affiliations

¹ Meat Animal Research Center (USMARC), Clay Center, USDA, ARS, Clay Center, Nebraska, USA mike.heaton@ars.usda.gov.
² Meat Animal Research Center (USMARC), Clay Center, USDA, ARS, Clay Center, Nebraska, USA.

Abstract

Mannheimia haemolytica is a bacterial pathogen that secretes leukotoxin (LktA) which binds to leukocyte membranes via CD18, causing bacterial pneumonia in ruminants. We report the complete closed genome sequences of a leukotoxin mutant and its parent strain that are frequently used in respiratory disease studies.