Metoclopramide-induced parkinsonism

South Med J. 1989 Dec;82(12):1581-2. doi: 10.1097/00007611-198912000-00033.


Metoclopramide hydrochloride (Reglan) is a widely prescribed drug for treatment of upper gastrointestinal symptoms. Although the drug is relatively safe, a growing body of literature has noted movement disorders after its administration. We have reported six cases of metoclopramide-induced parkinsonism seen in consultation over a two-year period. Five of these six patients had renal failure. Their parkinsonism improved on discontinuation of metoclopramide therapy. Metoclopramide-induced parkinsonism is not rare, and appropriate dose reduction in patients with renal failure will help reduce the incidence of this morbidity.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Aged
  • Female
  • Follow-Up Studies
  • Humans
  • Kidney Failure, Chronic / drug therapy
  • Male
  • Metoclopramide / adverse effects*
  • Middle Aged
  • Parkinson Disease, Secondary / chemically induced*
  • Time Factors


  • Metoclopramide