Neuroimaging and Anxiety: the Neural Substrates of Pathological and Non-pathological Anxiety

Curr Psychiatry Rep. 2015 Jun;17(6):49. doi: 10.1007/s11920-015-0586-9.


Advances in the use of noninvasive neuroimaging to study the neural correlates of pathological and non-pathological anxiety have shone new light on the underlying neural bases for both the development and manifestation of anxiety. This review summarizes the most commonly observed neural substrates of the phenotype of anxiety. We focus on the neuroimaging paradigms that have shown promise in exposing this relevant brain circuitry. In this way, we offer a broad overview of how anxiety is studied in the neuroimaging laboratory and the key findings that offer promise for future research and a clearer understanding of anxiety.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Amygdala / pathology
  • Anxiety / pathology*
  • Anxiety Disorders / pathology*
  • Brain / pathology*
  • Cerebral Cortex / pathology
  • Gyrus Cinguli / pathology
  • Humans
  • Neuroimaging* / methods
  • Prefrontal Cortex / pathology