Refining the chemical toolbox to be fit for educational and practical purpose for drug discovery in the 21st Century

Drug Discov Today. 2015 Aug;20(8):1018-26. doi: 10.1016/j.drudis.2015.04.010. Epub 2015 May 7.


We live in a time where exploration and generation of new knowledge is occurring on a colossal scale. Medicinal chemists have traditionally taken key roles in drug discovery; however, the many unmet medical demands in the healthcare sector emphasise the need to evolve the medicinal chemistry discipline. To rise to the challenges in the 21st Century there is a necessity to refine the chemical toolbox for educational and practical reasons. This review proposes modern strategies that are beneficial to teaching in academia but are also important reminders of strategies that can potentially lead to better drugs.

Publication types

  • Historical Article
  • Review

MeSH terms

  • Animals
  • Chemistry, Pharmaceutical / education*
  • Chemistry, Pharmaceutical / trends
  • Computer-Aided Design
  • Curriculum
  • Diffusion of Innovation
  • Drug Design
  • Drug Discovery / education*
  • Drug Discovery / trends
  • Education, Professional / methods*
  • Forecasting
  • History, 21st Century
  • Humans
  • Molecular Structure
  • Pharmaceutical Preparations / administration & dosage
  • Pharmaceutical Preparations / chemistry*
  • Pharmaceutical Preparations / metabolism
  • Pharmacokinetics
  • Quantitative Structure-Activity Relationship
  • Teaching / methods*


  • Pharmaceutical Preparations