Abstract
Engineering natural macrophage cell membrane-camouflaged mesoporous silica nanocapsules can reduce the arrested percentage of immune cells and tissues, effectively prolong the survival time of nanoparticles in blood circulation system, and improve the accumulation in tumor.
Keywords:
blood circulation; cell membrane; chemotherapy; drug delivery; mesoporous silica nanocapsules.
© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antibiotics, Antineoplastic / administration & dosage
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Antibiotics, Antineoplastic / chemistry
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Antibiotics, Antineoplastic / toxicity
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Cell Line, Tumor
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Cell Survival / drug effects
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Doxorubicin / administration & dosage
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Doxorubicin / chemistry
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Doxorubicin / toxicity
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Drug Carriers / chemistry
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Macrophages / cytology
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Macrophages / drug effects
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Macrophages / metabolism
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Male
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Mice
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Mice, Inbred BALB C
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Mice, Nude
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Nanocapsules / chemistry*
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Neoplasms / drug therapy
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Phagocytosis / drug effects
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Porosity
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Silicon Dioxide / chemistry*
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Tissue Distribution
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Transplantation, Homologous
Substances
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Antibiotics, Antineoplastic
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Drug Carriers
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Nanocapsules
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Silicon Dioxide
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Doxorubicin