Autoimmune/auto-inflammatory syndrome induced by adjuvants (ASIA) after quadrivalent human papillomavirus vaccination in Colombians: a call for personalised medicine

Clin Exp Rheumatol. Jul-Aug 2015;33(4):545-8. Epub 2015 May 11.

Abstract

This was a case study in which 3 patients with autoimmune/auto-inflammatory syndrome induced by adjuvants (ASIA) after quadrivalent human papillomavirus vaccination (HPV) were evaluated and described. All the patients were women. Diagnosis consisted of HLA-B27 enthesitis related arthritis, rheumatoid arthritis and systemic lupus erythematous, respectively. Our results highlight the risk of developing ASIA after HPV vaccination and may serve to increase the awareness of such a complication. Factors that are predictive of developing autoimmune diseases should be examined at the population level in order to establish preventive measures in at-risk individuals for whom healthcare should be personalized and participatory.

Publication types

  • Case Reports

MeSH terms

  • Adjuvants, Immunologic / administration & dosage
  • Adjuvants, Immunologic / adverse effects*
  • Adolescent
  • Antirheumatic Agents / administration & dosage
  • Arthritis, Juvenile* / etiology
  • Arthritis, Juvenile* / immunology
  • Arthritis, Juvenile* / physiopathology
  • Arthritis, Juvenile* / therapy
  • Arthritis, Rheumatoid* / drug therapy
  • Arthritis, Rheumatoid* / etiology
  • Arthritis, Rheumatoid* / immunology
  • Arthritis, Rheumatoid* / physiopathology
  • Autoantibodies / blood
  • Female
  • Glucocorticoids / administration & dosage
  • HLA-B27 Antigen / blood
  • Humans
  • Lupus Erythematosus, Systemic* / drug therapy
  • Lupus Erythematosus, Systemic* / etiology
  • Lupus Erythematosus, Systemic* / immunology
  • Lupus Erythematosus, Systemic* / physiopathology
  • Papillomavirus Infections / prevention & control*
  • Papillomavirus Vaccines / administration & dosage
  • Papillomavirus Vaccines / adverse effects*
  • Treatment Outcome
  • Uterine Cervical Neoplasms / prevention & control*
  • Young Adult

Substances

  • Adjuvants, Immunologic
  • Antirheumatic Agents
  • Autoantibodies
  • Glucocorticoids
  • HLA-B27 Antigen
  • Papillomavirus Vaccines