Surgery for liver metastases from breast cancer

Future Oncol. 2015;11(10):1519-30. doi: 10.2217/fon.15.43.

Abstract

Introduction: Liver metastases from breast cancer (BCLM) confer poor survival. Liver resection in BCLM patients has been increasingly employed.

Aim: We undertook a systematic review to evaluate the role of hepatic resection in patients with breast cancer metastatic to the liver.

Materials & methods: In total, 36 studies were overviewed. Patient populations, characteristics, morbidity, mortality and survival were documented.

Results: Median overall survival was 41 months. Major morbidity was rare while 30-day postoperative mortality was near nil.

Conclusion: Liver surgery for BCLM can be performed with low mortality, acceptable morbidity and promising survival benefit in carefully selected patients.

Keywords: breast cancer; chemotherapy; hepatectomy; liver metastases; metastasectomy; resection; surgery; survival.

Publication types

  • Meta-Analysis
  • Review
  • Systematic Review

MeSH terms

  • Breast Neoplasms / epidemiology
  • Breast Neoplasms / mortality
  • Breast Neoplasms / pathology*
  • Female
  • Humans
  • Liver Neoplasms / epidemiology
  • Liver Neoplasms / mortality
  • Liver Neoplasms / secondary*
  • Liver Neoplasms / surgery*
  • Morbidity
  • Mortality
  • Retreatment
  • Treatment Outcome