Epigenetics meets immune checkpoints

Semin Oncol. 2015 Jun;42(3):506-13. doi: 10.1053/j.seminoncol.2015.02.003. Epub 2015 Feb 14.

Abstract

Epigenetic alterations play a pivotal role in cancer development and progression. Pharmacologic reversion of such alterations is feasible, and second generation "epigenetic drugs" are in development and have been demonstrated to possess significant immunomodulatory properties. This knowledge, together with the availability of new and highly effective immunotherapeutic agents including immune checkpoint(s) blocking monoclonal antibodies, allows us to plan for highly innovative proof-of-principle combination studies that will likely open the path to more effective anticancer therapies.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents / pharmacology
  • Antineoplastic Agents / therapeutic use
  • Azacitidine / analogs & derivatives
  • Azacitidine / pharmacology
  • Azacitidine / therapeutic use
  • DNA Methylation / drug effects
  • Epigenesis, Genetic / drug effects*
  • Humans
  • Immunomodulation / drug effects
  • Immunomodulation / genetics
  • Immunotherapy
  • Neoplasms / drug therapy
  • Neoplasms / genetics*
  • Neoplasms / immunology*

Substances

  • Antineoplastic Agents
  • guadecitabine
  • Azacitidine