An improved and efficient synthesis of (+)-cloprostenol has been accomplished in nine steps and 26% overall yield from commercially available (-)-Corey lactone 4-phenylbenzoate alcohol . The present route avoids tedious purifications and requires only one column chromatography operation, which reduces the generation of waste and is suitable for large-scale preparation.
Keywords: (+)-cloprostenol; Corey lactone; asymmetric reduction; process development; prostaglandin; synthesis.
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