Polymorphisms in the SIRT5 gene and their association with body measurement and ultrasound traits in Qinchuan cattle

Genet Mol Res. 2015 Apr 22;14(2):3843-53. doi: 10.4238/2015.April.22.13.


Silent information regulator 5 (SIRT5), a member of the Sirtuin family class III nicotinamide adenine dinucleotide-dependent protein deacetylases, plays an important role in metabolic and aging processes in mammals. We identified 4 single-nucleotide polymorphisms (SNPs) (G22010A, G22052A, G22119T, and G22245C) in the 3' untranslated regions of the SIRT5 gene from 572 Qinchuan cattle by sequencing and investigating their association with growth and ultrasound traits. The frequencies of genotype GG and allele G were high at the 4 SNPs. Based on the X(2) test, the genotypic distributions of the 4 SNPs were not in Hardy-Weinberg equilibrium (P < 0.05 or P < 0.01). Association analysis of individual SNPs and haplotype combinations revealed that the 4 loci were significantly associated with some body measurement and ultrasound traits in Qinchuan cattle, and the H1H5 (AG-GA-GG-GG) diplotypes had better performance than other combinations in Qinchuan cattle. Our results demonstrate that SIRT5 may be a candidate for marker-assisted selection in future breeding programs for Qinchuan cattle.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Base Sequence
  • Body Size / genetics
  • Breeding
  • Cattle / anatomy & histology
  • Cattle / genetics*
  • Cattle / growth & development
  • Gene Frequency
  • Genetic Association Studies
  • Genetic Loci
  • Linkage Disequilibrium
  • Muscle, Skeletal / anatomy & histology
  • Muscle, Skeletal / diagnostic imaging
  • Polymorphism, Single Nucleotide*
  • Sequence Analysis, DNA
  • Sirtuins / genetics*
  • Subcutaneous Fat / anatomy & histology
  • Subcutaneous Fat / diagnostic imaging
  • Ultrasonography


  • Sirtuins