Effect of Dietary Resistant Starch on Prevention and Treatment of Obesity-related Diseases and Its Possible Mechanisms

Biomed Environ Sci. 2015 Apr;28(4):291-7. doi: 10.3967/bes2015.040.


Overweight or obesity has become a serious public health problem in the world, scientists are concentrating their efforts on exploring novel ways to treat obesity. Nowadays, the availabilities of bariatric surgery and pharmacotherapy have enhanced obesity treatment, but it should has support from diet, physical exercise and lifestyle modification, especially the functional food. Resistant starch, an indigestible starch, has been studied for years for its beneficial effects on regulating blood glucose level and lipid metabolism. The aim of this review is to summarize the effect of resistant starch on weight loss and the possible mechanisms. According to numerous previous studies it could be concluded that resistant starch can reduce fat accumulation, enhance insulin sensitivity, regulate blood glucose level and lipid metabolism. Recent investigations have focused on the possible associations between resistant starch and incretins as well as gut microbiota. Resistant starch seems to be a promising dietary fiber for the prevention or treatment of obesity and its related diseases.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Dietary Carbohydrates / metabolism
  • Dietary Fiber / metabolism
  • Dietary Fiber / therapeutic use
  • Gastrointestinal Tract / microbiology
  • Gastrointestinal Tract / physiology*
  • Microbiota
  • Obesity / diet therapy*
  • Obesity / prevention & control*
  • Starch / metabolism*
  • Weight Loss


  • Dietary Carbohydrates
  • Dietary Fiber
  • Starch