Golgi post-translational modifications and associated diseases

J Inherit Metab Dis. 2015 Jul;38(4):741-51. doi: 10.1007/s10545-015-9851-7. Epub 2015 May 13.


For non specialists, Golgi is a very well known subcellular compartment involved in secretion and correct targeting of soluble and transmembrane proteins. Nevertheless, Golgi is also specifically involved in many different and diverse post-translational modifications. Through its diverse functions, Golgi is not only able to modify secreted and transmembrane proteins but also cytoplasmic proteins. The Golgi apparatus research field is so broad that an exhaustive review of this organelle is not doable here. The goal of this review is to cover the main post-translational modifications occurring at the Golgi level and present the identified associated diseases.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Golgi Apparatus / genetics*
  • Golgi Apparatus / metabolism*
  • Humans
  • Metabolic Diseases / genetics*
  • Metabolic Diseases / metabolism*
  • Protein Processing, Post-Translational / genetics*