Isolation of a cDNA clone and localization of the human glutathione S-transferase 3 genes to chromosome bands 11q13 and 12q13-14

Ann Hum Genet. 1989 Jul;53(3):205-13. doi: 10.1111/j.1469-1809.1989.tb01786.x.


A partial cDNA clone of the glutathione S-transferase 3 gene (GST3) was obtained by screening a lambda gt11 human lung cDNA library with antiserum to human lung GST3. The sequence of this cDNA showed two base differences from the coding sequence of a GST3 cDNA isolated from a human placental cDNA library. Hybridization of the cloned GST3 cDNA to human chromosomes resulted in a primary peak of grains over band 11q13, a localization predicted by prior experiments. An unexpected strong secondary peak of grains was obtained over bands 12q13 and 12q14, indicating that there is a GST3-like gene on the long arm of chromosome 12 in man.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • Chromosome Banding*
  • Chromosomes, Human, Pair 11*
  • Chromosomes, Human, Pair 12*
  • DNA / isolation & purification*
  • Glutathione Transferase / genetics*
  • Humans
  • Isoenzymes / isolation & purification*
  • Molecular Sequence Data
  • Nucleic Acid Hybridization


  • Isoenzymes
  • DNA
  • Glutathione Transferase