Variants in the Mannose-binding Lectin Gene MBL2 Do Not Associate With Sepsis Susceptibility or Survival in a Large European Cohort

Clin Infect Dis. 2015 Sep 1;61(5):695-703. doi: 10.1093/cid/civ378. Epub 2015 May 12.

Abstract

Background: Sepsis is an increasingly common condition, which continues to be associated with unacceptably high mortality. A large number of association studies have investigated susceptibility to, or mortality from, sepsis for variants in the functionally important immune-related gene MBL2. These studies have largely been underpowered and contradictory.

Methods: We genotyped and analyzed 4 important MBL2 single nucleotide polymorphisms (SNPs; rs5030737, rs1800450, rs1800451, and rs7096206) in 1839 European community-acquired pneumonia (CAP) and peritonitis sepsis cases, and 477 controls from the United Kingdom. We analyzed the following predefined subgroups and outcomes: 28-day and 6 month mortality from sepsis due to CAP or peritonitis combined, 28-day mortality from CAP sepsis, peritonitis sepsis, pneumococcal sepsis or sepsis in younger patients, and susceptibility to CAP sepsis or pneumococcal sepsis in the United Kingdom.

Results: There were no significant associations (all P-values were greater than .05 after correction for multiple testing) between MBL2 genotypes and any of our predefined analyses.

Conclusions: In this large, well-defined cohort of immune competent adult patients, no associations between MBL2 genotype and sepsis susceptibility or outcome were identified.

Keywords: MBL; association study; genetics; mannose-binding lectin; sepsis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Cohort Studies
  • Female
  • Genetic Predisposition to Disease / genetics*
  • Humans
  • Male
  • Mannose-Binding Lectin / genetics*
  • Middle Aged
  • Polymorphism, Single Nucleotide / genetics
  • Sepsis / epidemiology*
  • Sepsis / genetics*

Substances

  • MBL2 protein, human
  • Mannose-Binding Lectin