Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 524 (7563), 93-6

Genetic Diversity and Evolutionary Dynamics of Ebola Virus in Sierra Leone

Collaborators, Affiliations

Genetic Diversity and Evolutionary Dynamics of Ebola Virus in Sierra Leone

Yi-Gang Tong et al. Nature.

Erratum in

  • Erratum: Genetic diversity and evolutionary dynamics of Ebola virus in Sierra Leone.
    Tong YG, Shi WF, Liu D, Qian J, Liang L, Bo XC, Liu J, Ren HG, Fan H, Ni M, Sun Y, Jin Y, Teng Y, Li Z, Kargbo D, Dafae F, Kanu A, Chen CC, Lan ZH, Jiang H, Luo Y, Lu HJ, Zhang XG, Yang F, Hu Y, Cao YX, Deng YQ, Su HX, Sun Y, Liu WS, Wang Z, Wang CY, Bu ZY, Guo ZD, Zhang LB, Nie WM, Bai CQ, Sun CH, An XP, Xu PS, Zhang XL, Huang Y, Mi ZQ, Yu D, Yao HW, Feng Y, Xia ZP, Zheng XX, Yang ST, Lu B, Jiang JF, Kargbo B, He FC, Gao GF, Cao WC; China Mobile Laboratory Testing Team in Sierra Leone. Tong YG, et al. Nature. 2015 Oct 22;526(7574):595. doi: 10.1038/nature15255. Epub 2015 Aug 26. Nature. 2015. PMID: 26308898 No abstract available.


A novel Ebola virus (EBOV) first identified in March 2014 has infected more than 25,000 people in West Africa, resulting in more than 10,000 deaths. Preliminary analyses of genome sequences of 81 EBOV collected from March to June 2014 from Guinea and Sierra Leone suggest that the 2014 EBOV originated from an independent transmission event from its natural reservoir followed by sustained human-to-human infections. It has been reported that the EBOV genome variation might have an effect on the efficacy of sequence-based virus detection and candidate therapeutics. However, only limited viral information has been available since July 2014, when the outbreak entered a rapid growth phase. Here we describe 175 full-length EBOV genome sequences from five severely stricken districts in Sierra Leone from 28 September to 11 November 2014. We found that the 2014 EBOV has become more phylogenetically and genetically diverse from July to November 2014, characterized by the emergence of multiple novel lineages. The substitution rate for the 2014 EBOV was estimated to be 1.23 × 10(-3) substitutions per site per year (95% highest posterior density interval, 1.04 × 10(-3) to 1.41 × 10(-3) substitutions per site per year), approximating to that observed between previous EBOV outbreaks. The sharp increase in genetic diversity of the 2014 EBOV warrants extensive EBOV surveillance in Sierra Leone, Guinea and Liberia to better understand the viral evolution and transmission dynamics of the ongoing outbreak. These data will facilitate the international efforts to develop vaccines and therapeutics.

Comment in

Similar articles

  • Temporal and spatial analysis of the 2014-2015 Ebola virus outbreak in West Africa.
    Carroll MW, Matthews DA, Hiscox JA, Elmore MJ, Pollakis G, Rambaut A, Hewson R, García-Dorival I, Bore JA, Koundouno R, Abdellati S, Afrough B, Aiyepada J, Akhilomen P, Asogun D, Atkinson B, Badusche M, Bah A, Bate S, Baumann J, Becker D, Becker-Ziaja B, Bocquin A, Borremans B, Bosworth A, Boettcher JP, Cannas A, Carletti F, Castilletti C, Clark S, Colavita F, Diederich S, Donatus A, Duraffour S, Ehichioya D, Ellerbrok H, Fernandez-Garcia MD, Fizet A, Fleischmann E, Gryseels S, Hermelink A, Hinzmann J, Hopf-Guevara U, Ighodalo Y, Jameson L, Kelterbaum A, Kis Z, Kloth S, Kohl C, Korva M, Kraus A, Kuisma E, Kurth A, Liedigk B, Logue CH, Lüdtke A, Maes P, McCowen J, Mély S, Mertens M, Meschi S, Meyer B, Michel J, Molkenthin P, Muñoz-Fontela C, Muth D, Newman EN, Ngabo D, Oestereich L, Okosun J, Olokor T, Omiunu R, Omomoh E, Pallasch E, Pályi B, Portmann J, Pottage T, Pratt C, Priesnitz S, Quartu S, Rappe J, Repits J, Richter M, Rudolf M, Sachse A, Schmidt KM, Schudt G, Strecker T, Thom R, Thomas S, Tobin E, Tolley H, Trautner J, Vermoesen T, Vitoriano I, Wagner M, Wolff S, Yue C, Capobianchi MR, Kretschmer B, Hall Y, Kenny JG, Rickett NY, Dudas G, Coltart CE, Kerber R, Steer D, Wright C, Senyah F, Keita S, Drury P, Diallo B, de Clerck H, Van Herp M, Sprecher A, Traore A, Diakite M, Konde MK, Koivogui L, Magassouba N, Avšič-Županc T, Nitsche A, Strasser M, Ippolito G, Becker S, Stoecker K, Gabriel M, Raoul H, Di Caro A, Wölfel R, Formenty P, Günther S. Carroll MW, et al. Nature. 2015 Aug 6;524(7563):97-101. doi: 10.1038/nature14594. Epub 2015 Jun 17. Nature. 2015. PMID: 26083749
  • Distinct lineages of Ebola virus in Guinea during the 2014 West African epidemic.
    Simon-Loriere E, Faye O, Faye O, Koivogui L, Magassouba N, Keita S, Thiberge JM, Diancourt L, Bouchier C, Vandenbogaert M, Caro V, Fall G, Buchmann JP, Matranga CB, Sabeti PC, Manuguerra JC, Holmes EC, Sall AA. Simon-Loriere E, et al. Nature. 2015 Aug 6;524(7563):102-4. doi: 10.1038/nature14612. Epub 2015 Jun 24. Nature. 2015. PMID: 26106863
  • Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak.
    Gire SK, Goba A, Andersen KG, Sealfon RS, Park DJ, Kanneh L, Jalloh S, Momoh M, Fullah M, Dudas G, Wohl S, Moses LM, Yozwiak NL, Winnicki S, Matranga CB, Malboeuf CM, Qu J, Gladden AD, Schaffner SF, Yang X, Jiang PP, Nekoui M, Colubri A, Coomber MR, Fonnie M, Moigboi A, Gbakie M, Kamara FK, Tucker V, Konuwa E, Saffa S, Sellu J, Jalloh AA, Kovoma A, Koninga J, Mustapha I, Kargbo K, Foday M, Yillah M, Kanneh F, Robert W, Massally JL, Chapman SB, Bochicchio J, Murphy C, Nusbaum C, Young S, Birren BW, Grant DS, Scheiffelin JS, Lander ES, Happi C, Gevao SM, Gnirke A, Rambaut A, Garry RF, Khan SH, Sabeti PC. Gire SK, et al. Science. 2014 Sep 12;345(6202):1369-72. doi: 10.1126/science.1259657. Epub 2014 Aug 28. Science. 2014. PMID: 25214632 Free PMC article.
  • [Control of Ebola hemorrhagic fever: vaccine development and our Ebola project in Sierra Leone].
    Watanabe T, Kawaoka Y. Watanabe T, et al. Uirusu. 2016;66(1):53-62. doi: 10.2222/jsv.66.53. Uirusu. 2016. PMID: 28484179 Review. Japanese.
  • Progression of Ebola Therapeutics During the 2014-2015 Outbreak.
    Mendoza EJ, Qiu X, Kobinger GP. Mendoza EJ, et al. Trends Mol Med. 2016 Feb;22(2):164-173. doi: 10.1016/j.molmed.2015.12.005. Epub 2016 Jan 13. Trends Mol Med. 2016. PMID: 26774636 Review.
See all similar articles

Cited by 78 articles

See all "Cited by" articles


    1. Nature. 2005 Dec 1;438(7068):575-6 - PubMed
    1. Mol Biol Evol. 2013 Apr;30(4):772-80 - PubMed
    1. MBio. 2015 Jan 20;6(1):null - PubMed
    1. Epidemiol Infect. 2014 Jun;142(6):1138-45 - PubMed
    1. Mol Biol Evol. 2008 Jul;25(7):1459-71 - PubMed

Publication types