ROS signaling and redox biology in endothelial cells

Cell Mol Life Sci. 2015 Sep;72(17):3281-303. doi: 10.1007/s00018-015-1928-9. Epub 2015 May 14.


The purpose of this review is to provide an overview of redox mechanisms, sources and antioxidants that control signaling events in ECs. In particular, we describe which molecules are involved in redox signaling and how they influence the relationship between ECs and other vascular component with regard to angiogenesis. Recent and new tools to investigate physiological ROS signaling will be also discussed. Such findings are providing an overview of the ROS biology relevant for endothelial cells in the context of normal and pathological angiogenic conditions.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Endothelial Cells / metabolism*
  • Humans
  • Mitochondria / metabolism*
  • NADPH Oxidases / metabolism*
  • Neovascularization, Physiologic / physiology*
  • Oxidation-Reduction*
  • Protein Tyrosine Phosphatases / metabolism
  • Reactive Oxygen Species / metabolism*
  • Signal Transduction / physiology*


  • Reactive Oxygen Species
  • NADPH Oxidases
  • Protein Tyrosine Phosphatases