Serum Uric Acid and Prehypertension Among Adults Free of Cardiovascular Diseases and Diabetes: Baseline of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)

Angiology. 2016 Feb;67(2):180-6. doi: 10.1177/0003319715585037. Epub 2015 May 13.


The association between serum uric acid (SUA) and prehypertension was evaluated in a racially admixed sample of civil servants aged 35 to 74 years, enrolled (2008-2010) in the Brazilian Longitudinal Study of Health (ELSA-Brasil). Of the 15 105 patients who enrolled in the study, we analyzed 3412 after excluding those who reported previous cardiovascular diseases, diabetes, or hypertension; were heavy drinkers; or had a body mass index (BMI) ≥ 35 kg/m(2). Among the men, logistic regression, adjusted for age, race, income, birth weight, salt intake, insulin resistance, BMI, and renal function revealed odds ratios (ORs) and 95% confidence intervals (CIs) of prehypertension from the bottom quartile (referent) to the top quartile of SUA levels as follows: 0.84 (95% CI, 0.61-1.38), 0.97 (0.71-1.34) and 1.44 (1.04-2.0; P for trend .01). Analyzing for 1-standard deviation of change in SUA, the ORs were 1.19 (1.06-1.32). This association persisted in the subgroup analysis consisting of patients who were white, overweight, with a high salt intake but with normal renal function, and without metabolic syndrome. No association was found among women. In conclusion, SUA levels were associated with prehypertension among men.

Keywords: birth weight; insulin resistance; obesity; preeclampsia; salt intake; subclinical atherosclerosis; uricase.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Age Factors
  • Aged
  • Biomarkers / blood
  • Blood Pressure*
  • Brazil / epidemiology
  • Comorbidity
  • Female
  • Health Surveys
  • Humans
  • Hyperuricemia / blood
  • Hyperuricemia / diagnosis
  • Hyperuricemia / epidemiology*
  • Life Style
  • Logistic Models
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Odds Ratio
  • Prehypertension / diagnosis
  • Prehypertension / epidemiology*
  • Prehypertension / physiopathology
  • Risk Factors
  • Sex Factors
  • Uric Acid / blood*


  • Biomarkers
  • Uric Acid