Inhibition of soybean 15-lipoxygenase by naturally occurring acetophenones and derricidin

Nat Prod Commun. 2015 Apr;10(4):589-90.

Abstract

Three selected naturally occurring oxyprenylated secondary metabolites, namely 2-hydroxy4-isopentenyloxyacetophenone (1), 4-geranyloxy-2-hydroxyacetophenone (2), 4-farnesyloxyacetophenone (3), and derricidin (4) were synthesized and their inhibitory potency against soybean 15-lipoxygenase evaluated. Compounds 1 and 4 showed the most potent inhibitory activity with ICo50 values of 2.5 µM and 0.6 µM.

MeSH terms

  • Acetophenones / chemistry
  • Acetophenones / pharmacology*
  • Arachidonate 15-Lipoxygenase / metabolism*
  • Flavonoids / chemistry
  • Flavonoids / pharmacology*
  • Glycine max / enzymology*
  • Lipoxygenase Inhibitors / chemistry*
  • Lipoxygenase Inhibitors / pharmacology*
  • Molecular Structure

Substances

  • Acetophenones
  • Flavonoids
  • Lipoxygenase Inhibitors
  • derricidin
  • Arachidonate 15-Lipoxygenase