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Review
, 82 (5), 295-300

Penicillin Allergy: A Practical Guide for Clinicians

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Review

Penicillin Allergy: A Practical Guide for Clinicians

Alexei Gonzalez-Estrada et al. Cleve Clin J Med.

Abstract

Penicillin allergy is the most commonly reported drug allergy in the United States. However, after undergoing a complete evaluation by a board-certified allergist, including skin testing, 90% of patients labeled as 'penicillin-allergic' are able to tolerate penicillin. Clinical presentation is key in classifying reactions as either mediated by or not mediated by immunoglobulin E (IgE), and in determining which patients may benefit from penicillin skin testing, graded-dose challenge, or desensitization. Cross-reactivity between penicillin and other beta-lactams is less common than previously thought.

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