Friend turned foe: a role for bacterial sulfatases in colitis

Maria Chatzidaki-Livanis; Laurie E Comstock

doi:10.1016/j.chom.2015.04.012

Friend turned foe: a role for bacterial sulfatases in colitis

Cell Host Microbe. 2015 May 13;17(5):540-1. doi: 10.1016/j.chom.2015.04.012.

Authors

Maria Chatzidaki-Livanis¹, Laurie E Comstock²

Affiliations

¹ Division of Infectious Diseases, Brigham and Women's Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA.
² Division of Infectious Diseases, Brigham and Women's Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA. Electronic address: lcomstock@rics.bwh.harvard.edu.

PMID: 25974293
DOI: 10.1016/j.chom.2015.04.012

Abstract

During colitis, gut bacteria and bacterial components can traverse the mucus layer and contact host cells. In this issue of Cell Host & Microbe, Hickey et al. (2015) show that sulfatases of Bacteroides thetaiotaomicron are required for its outer membrane vesicles to transit to underlying host immune cells and cause colitis.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Animals
Antigens, Bacterial / metabolism*
Bacteroides / metabolism*
Colitis / microbiology*
Host-Pathogen Interactions*
Secretory Vesicles / enzymology*
Secretory Vesicles / metabolism*
Sulfatases / metabolism*

Substances

Antigens, Bacterial
Sulfatases

Abstract

Publication types

MeSH terms

Substances

Grants and funding