CoQ₁₀ Function and Role in Heart Failure and Ischemic Heart Disease

Annu Rev Nutr. 2015;35:175-213. doi: 10.1146/annurev-nutr-071714-034258. Epub 2015 May 13.


Coenzyme Q (CoQ) is an essential lipid of cells present in all cellular compartments. The functions of CoQ in mitochondrial respiration and as an antioxidant are established, although the lipid likely has additional, presently unknown, roles. While the therapeutic utility of CoQ10 supplements is recognized in the rare cases of primary CoQ10 deficiencies, a potential role for CoQ10 supplements in cardiovascular disease, particularly heart failure, has also been studied for over 40 years. This review summarizes our current knowledge in these areas derived from animal studies and human trials. Current evidence for a benefit of CoQ10 supplements in diseases other than primary CoQ10 deficiencies is insufficient.

Keywords: cardiovascular disease; subcellular distribution; therapy; ubiquinol; ubiquinone.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Age Factors
  • Animals
  • Antioxidants
  • Diet
  • Dietary Supplements
  • Heart Failure* / drug therapy
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / adverse effects
  • Muscle, Skeletal
  • Muscular Diseases / chemically induced
  • Muscular Diseases / prevention & control
  • Myocardial Ischemia* / drug therapy
  • Tissue Distribution
  • Ubiquinone / administration & dosage
  • Ubiquinone / analogs & derivatives*
  • Ubiquinone / deficiency
  • Ubiquinone / physiology


  • Antioxidants
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Ubiquinone
  • coenzyme Q10