Phototherapeutic Effect of Low-Level Laser on Thyroid Gland of Gamma-Irradiated Rats

Photochem Photobiol. 2015 Jul-Aug;91(4):942-51. doi: 10.1111/php.12465. Epub 2015 Jun 4.


One inescapable feature of life on the earth is exposure to ionizing radiation. The thyroid gland is one of the most sensitive organs to gamma-radiation and endocrine disrupters. Low-level laser therapy (LLLT) has been used to stimulate tissue repair, and reduce inflammation. The aim of this study was to gauge the value of using Helium-Neon laser to repair the damaged tissues of thyroid gland after gamma-irradiation. Albino rats were used in this study (144 rats), divided into control, gamma, laser, and gamma plus laser-irradiated groups, each group was divided into six subgroups according to time of treatment (total six sessions). Rats were irradiated once with gamma radiation (6 Gy), and an external dose of laser (Wavelength 632.8 nm, 12 mW, CW, Illuminated area 5.73 cm(2), 2.1 mW cm(-2) 120 s, 1.4 J, 0.252 J cm(-2)) twice weekly localized on thyroid region of the neck, for a total of six sessions. Animals were sacrificed after each session. Analysis included thyroid function, oxidative stress markers, liver function and blood picture. Results revealed improvement in thyroid function, liver function and antioxidant levels, and the blood cells count after LLLT.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Gamma Rays*
  • Low-Level Light Therapy*
  • Male
  • Phototherapy*
  • Rats
  • Rats, Wistar
  • Thyroid Gland / radiation effects*