Targeting drug sensitivity predictors: New potential strategies to improve pharmacotherapy of human brain disorders

Prog Neuropsychopharmacol Biol Psychiatry. 2015 Dec 3;63:76-82. doi: 10.1016/j.pnpbp.2015.05.004. Epub 2015 May 11.


One of the main challenges in medicine is the lack of efficient drug therapies for common human disorders. For example, although depressed patients receive powerful antidepressants, many often remain resistant to psychopharmacotherapy. The growing recognition of complex interplay between the drug targets and the predictors of drug sensitivity requires an improved understanding of these two key aspects of drug action and their potentially shared molecular networks. Here, we apply the concept of endophenotypes and their interplay to drug action and sensitivity. Based on these analyses, we postulate that novel drugs may be developed by targeting specific molecular pathways that integrate drug targets with drug sensitivity predictors.

Keywords: Drug sensitivity predictor; Drug target; Efficacy; Endophenotype; Psychopharmacotherapy.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Brain Diseases / drug therapy*
  • Brain Diseases / genetics
  • Drug Delivery Systems / methods*
  • Humans
  • Models, Chemical
  • Neuroprotective Agents / therapeutic use*


  • Neuroprotective Agents