Prognostic value of troponins in acute nonmassive pulmonary embolism: A meta-analysis

Heart Lung. 2015 Jul-Aug;44(4):327-34. doi: 10.1016/j.hrtlng.2015.03.007. Epub 2015 May 11.


The objective of our meta-analysis is to update the evidence on the prognostic value of elevated troponin levels in patient with acute normotensive pulmonary embolism (PE). We did a systematic literature review of database, including Pubmed, EMBASE, and Cochrane. Studies were included if those were done on normotensive patients with acute PE and serum troponin assay was done. The primary end point was short term all cause mortality. The secondary end points were short term PE related mortality and serious adverse events. Elevated troponin levels were significantly associated with the increased risk for short term mortality (odds ratio [OR], 4.80; 95% CI, 3.25-7.08, I(2) = 54%), PE related mortality (OR, 3.80; 95% CI, 2.74-5.27, I(2) = 0%) and serious adverse events (OR, 3.65; 95% CI, 2.41-5.53, I(2) = 47%). Our study suggests that elevated levels of troponin identify a subgroup of patients with increased risk for short term mortality and serious adverse events.

Keywords: Mortality; Prognosis; Pulmonary embolism; Right ventricular dysfunction; Troponin.

Publication types

  • Meta-Analysis
  • Review
  • Systematic Review

MeSH terms

  • Acute Disease
  • Aged
  • Biomarkers / metabolism
  • Blood Pressure / physiology
  • Female
  • Humans
  • Male
  • Middle Aged
  • Odds Ratio
  • Prognosis
  • Pulmonary Embolism / mortality*
  • Pulmonary Embolism / physiopathology
  • Troponin / metabolism*


  • Biomarkers
  • Troponin