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Review
, 37 Suppl 1, 92-8

Hepcidin and Iron Disorders: New Biology and Clinical Approaches

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Review

Hepcidin and Iron Disorders: New Biology and Clinical Approaches

J Arezes et al. Int J Lab Hematol.

Abstract

Hepatic hormone hepcidin is a principal regulator of iron homeostasis and a pathogenic factor in common iron disorders. Hepcidin deficiency causes iron overload in hereditary hemochromatosis and iron-loading anemias, whereas hepcidin excess causes or contributes to the development of iron-restricted anemia in inflammatory diseases, infections, some cancers, and chronic kidney disease. Because of this, hepcidin may become a useful tool for diagnosis and management of iron disorders. Furthermore, a number of strategies that target hepcidin, its receptor, and its regulators are under development as novel therapeutic approaches for diseases associated with iron dysregulation.

Keywords: Hepcidin; anemia; ferroportin; iron; iron overload.

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