Nanoemulsion delivery systems for oil-soluble vitamins: Influence of carrier oil type on lipid digestion and vitamin D3 bioaccessibility

Food Chem. 2015 Nov 15:187:499-506. doi: 10.1016/j.foodchem.2015.04.065. Epub 2015 Apr 22.

Abstract

The influence of carrier oil type on the bioaccessibility of vitamin D3 encapsulated within oil-in-water nanoemulsions prepared using a natural surfactant (quillaja saponin) was studied using a simulated gastrointestinal tract (GIT) model: mouth; stomach; small intestine. The rate of free fatty acid release during lipid digestion decreased in the following order: medium chain triglycerides (MCT) > corn oil ≈ fish oil > orange oil > mineral oil. Conversely, the measured bioaccessibility of vitamin D3 decreased in the following order: corn oil ≈ fish oil > orange oil > mineral oil > MCT. These results show that carrier oil type has a considerable impact on lipid digestion and vitamin bioaccessibility, which was attributed to differences in the release of bioactives from lipid droplets, and their solubilization in mixed micelles. Nanoemulsions prepared using long chain triglycerides (corn or fish oil) were most effective at increasing vitamin bioaccessibility.

Keywords: Bioaccessibility; Bioavailability; Calcifediol; Calcitriol; Carrier oil; Cholecalciferol; Digestion; Nanoemulsions; Quillaja saponin; Vitamin D(3).

Publication types

  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biological Availability
  • Cholecalciferol / chemistry*
  • Cholecalciferol / metabolism
  • Digestion
  • Drug Carriers / chemistry*
  • Drug Delivery Systems / instrumentation
  • Drug Delivery Systems / methods*
  • Emulsions / chemistry
  • Emulsions / metabolism
  • Gastrointestinal Tract / metabolism
  • Humans
  • Models, Biological
  • Oils / chemistry*
  • Surface-Active Agents / chemistry

Substances

  • Drug Carriers
  • Emulsions
  • Oils
  • Surface-Active Agents
  • Cholecalciferol