Age-adjusted glycated albumin accurately reflects blood glucose in patients with neonatal diabetes mellitus: comparison with calculated glycated albumin determined by past blood glucose concentrations

Ann Clin Biochem. 2016 Jan;53(Pt 1):117-23. doi: 10.1177/0004563215589382. Epub 2015 May 14.

Abstract

Background: Glycated albumin is a useful glycaemic control indicator for neonatal diabetes mellitus. However, glycated albumin concentrations in infants are lower than those in adults and increase in an age-dependent manner. Based on our investigation of non-diabetic subjects, we proposed the possibility that the reference range for adults may be used regardless of age, provided that age-adjusted glycated albumin is employed. In the present study, we evaluate the usefulness of age-adjusted glycated albumin in neonatal diabetes mellitus patients.

Methods: Six neonatal diabetes mellitus patients (four patients with permanent neonatal diabetes mellitus and two patients with transient neonatal diabetes mellitus) were included. Measured glycated albumin or age-adjusted glycated albumin was compared to calculated glycated albumin, which was determined using calculation formulae we had reported based on past blood glucose over the 50 days before measurement of glycated albumin.

Results: Measured glycated albumin was significantly lower than calculated glycated albumin (20.5 ± 4.9% versus 28.2 ± 6.1%; p < 0.0001), whereas age-adjusted glycated albumin was equivalent to calculated glycated albumin, showing no significant difference (27.5 ± 6.8% versus 28.2 ± 6.1%). Measured glycated albumin concentrations in patients with transient neonatal diabetes mellitus in remission were lower than the reference range for adults, whereas age-adjusted glycated albumin concentrations were within the reference range for adults.

Conclusion: We demonstrated that age-adjusted glycated albumin concentrations were consistent with calculated glycated albumin. Age-adjusted glycated albumin is therefore a useful glycaemic control indicator for neonatal diabetes mellitus patients.

Keywords: Neonatal diabetes mellitus; glycaemic control indicator; glycated albumin.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Aging / blood*
  • Blood Chemical Analysis / methods*
  • Blood Glucose / analysis*
  • Diabetes Mellitus / blood*
  • Female
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Serum Albumin / analysis*

Substances

  • Blood Glucose
  • Serum Albumin
  • glycosylated serum albumin

Supplementary concepts

  • Diabetes Mellitus, Permanent Neonatal