Human olfactory receptor responses to odorants

Sci Data. 2015 Feb 3;2:150002. doi: 10.1038/sdata.2015.2. eCollection 2015.

Abstract

Although the human olfactory system is capable of discriminating a vast number of odors, we do not currently understand what chemical features are encoded by olfactory receptors. In large part this is due to a paucity of data in a search space covering the interactions of hundreds of receptors with billions of odorous molecules. Of the approximately 400 intact human odorant receptors, only 10% have a published ligand. Here we used a heterologous luciferase assay to screen 73 odorants against a clone library of 511 human olfactory receptors. This dataset will allow other researchers to interrogate the combinatorial nature of olfactory coding.

Publication types

  • Dataset
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biological Assay
  • Humans
  • Ligands*
  • Luciferases
  • Odorants
  • Receptors, Odorant* / metabolism

Substances

  • Ligands
  • Receptors, Odorant
  • Luciferases