PI3K-C2α: One enzyme for two products coupling vesicle trafficking and signal transduction

Carlo C Campa; Irene Franco; Emilio Hirsch

doi:10.1016/j.febslet.2015.05.001

PI3K-C2α: One enzyme for two products coupling vesicle trafficking and signal transduction

FEBS Lett. 2015 Jun 22;589(14):1552-8. doi: 10.1016/j.febslet.2015.05.001. Epub 2015 May 12.

Authors

Carlo C Campa¹, Irene Franco¹, Emilio Hirsch²

Affiliations

¹ Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino, Via Nizza 52, 10126 Torino, Italy.
² Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino, Via Nizza 52, 10126 Torino, Italy. Electronic address: emilio.hirsch@unito.it.

PMID: 25979177
DOI: 10.1016/j.febslet.2015.05.001

Abstract

The spatial restriction of phosphorylated phosphoinositides generated downstream activated membrane receptors is critical for proper cell response to environmental cues. The α isoform of class II PI3Ks, PI3K-C2α, has emerged as a modulator of receptor localization, acting both in the control of receptor endocytosis and resensitization. This unexpectedly versatile enzyme was found to differentially produce two distinct 3-phosphorylated phosphoinositides and to selectively control distinct steps of vesicular traffic such as endocytosis and recycling. This review focuses on the latest discoveries regarding PI3K-C2α function in vesicle trafficking and its impact on cell biology and mammalian embryonic development.

Keywords: Class II α-isoform of phosphatidylinositol 3-kinase; Endocytosis; Exocytosis; PI3K-C2α; Phosphoinositide; Signal transduction; Vesicle trafficking.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Enzyme Activation
Isoenzymes / metabolism*
Phosphatidylinositol 3-Kinases / metabolism*
Protein Transport*
Signal Transduction*

Substances

Isoenzymes
Phosphatidylinositol 3-Kinases

Grants and funding

GGP14106/TI_/Telethon/Italy