Mitochondrial degradation and energy metabolism

Biochim Biophys Acta. 2015 Oct;1853(10 Pt B):2812-21. doi: 10.1016/j.bbamcr.2015.05.010. Epub 2015 May 12.

Abstract

Mitochondria are intracellular power plants that feed most eukaryotic cells with the ATP produced by the oxidative phosphorylation (OXPHOS). Mitochondrial energy production is controlled by many regulatory mechanisms. The control of mitochondrial mass through both mitochondrial biogenesis and degradation has been proposed to be one of the most important regulatory mechanisms. Recently, autophagic degradation of mitochondria has emerged as an important mechanism involved in the regulation of mitochondrial quantity and quality. In this review, we highlight the intricate connections between mitochondrial energy metabolism and mitochondrial autophagic degradation by showing the importance of mitochondrial bioenergetics in this process and illustrating the role of mitophagy in mitochondrial patho-physiology. Furthermore, we discuss how energy metabolism could coordinate the biogenesis and degradation of this organelle.

Keywords: Mitochondrial energy metabolism; Mitochondrial turnover; Mitophagy.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Energy Metabolism / physiology*
  • Humans
  • Mitochondria / physiology*
  • Mitochondrial Dynamics / physiology*