Forcing contact inhibition of locomotion

Alice Roycroft; Roberto Mayor

doi:10.1016/j.tcb.2015.05.001

Forcing contact inhibition of locomotion

Trends Cell Biol. 2015 Jul;25(7):373-5. doi: 10.1016/j.tcb.2015.05.001. Epub 2015 May 13.

Authors

Alice Roycroft¹, Roberto Mayor²

Affiliations

¹ Department of Cell and Developmental Biology, University College London, Gower Street, London, WC1E 6BT, UK.
² Department of Cell and Developmental Biology, University College London, Gower Street, London, WC1E 6BT, UK. Electronic address: r.mayor@ucl.ac.uk.

Abstract

Contact inhibition of locomotion drives a variety of biological phenomenon, from cell dispersion to collective cell migration and cancer invasion. New imaging techniques have allowed contact inhibition of locomotion to be visualised in vivo for the first time, helping to elucidate some of the molecules and forces involved in this phenomenon.

Keywords: actin; biomechanics; contact inhibition of locomotion; forces; repulsion.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Biomechanical Phenomena
Cell Adhesion
Cell Movement
Contact Inhibition / physiology*
Drosophila melanogaster / cytology
Drosophila melanogaster / embryology
Embryo, Nonmammalian
Hemocytes / cytology
Hemocytes / physiology
Humans
Locomotion / physiology*
Xenopus laevis / embryology
Zebrafish / embryology

Abstract

Publication types

MeSH terms

Grants and funding