Borderline pulmonary pressures in scleroderma - a 'pre-pulmonary arterial hypertension' condition?

Arthritis Res Ther. 2015 May 18;17(1):123. doi: 10.1186/s13075-015-0649-7.


Patients with systemic sclerosis may develop borderline pulmonary arterial pressure. The clinical relevance of this condition is not always clear. Reported data support the evidence that this subgroup may represent an intermediate stage between normal pulmonary arterial pressure and manifest pulmonary arterial hypertension, a serious complication in scleroderma. Recognizing the clinical relevance of borderline pulmonary arterial pressure increase in scleroderma patients, future studies should aim for clear evidence for diagnostic and therapeutic algorithms for this population.

Publication types

  • Editorial

MeSH terms

  • Antihypertensive Agents / therapeutic use
  • Cohort Studies
  • Comorbidity
  • Disease Progression
  • Female
  • Humans
  • Hypertension, Pulmonary / diagnosis
  • Hypertension, Pulmonary / drug therapy
  • Hypertension, Pulmonary / epidemiology*
  • Incidence
  • Male
  • Prognosis
  • Pulmonary Wedge Pressure / physiology*
  • Risk Assessment
  • Scleroderma, Systemic / diagnosis
  • Scleroderma, Systemic / epidemiology*
  • Severity of Illness Index


  • Antihypertensive Agents