EMAS position statement: Non-hormonal management of menopausal vasomotor symptoms

Maturitas. 2015 Jul;81(3):410-3. doi: 10.1016/j.maturitas.2015.04.009. Epub 2015 Apr 22.


Aim: To review non-hormonal therapy options for menopausal vasomotor symptoms. The current EMAS position paper aims to provide to provide guidance for managing peri- and postmenopausal women who cannot or do not wish to take menopausal hormone therapy (MHT).

Material and methods: Literature review and consensus of expert opinion.

Results: Non-hormonal management of menopausal symptoms includes lifestyle modifications, diet and food supplements, non-hormonal medications and application of behavioral and alternative medicine therapies. There is insufficient or conflicting evidence to suggest that exercise, supplements or a diet rich in phytoestrogens are effective for vasomotor menopausal symptoms. Selective serotonin-reuptake inhibitors (SSRIs), serotonin norepinephrine-reuptake inhibitors (SNRIs) and gabapentin could be proposed as alternatives to MHT for menopausal symptoms, mainly hot flushes. Behavioral therapies and alternative medicine interventions have been tried, but the available evidence is still limited.

Conclusions: A number of interventions for non-hormonal management of menopausal vasomotor symptoms are now available. For women who cannot or do not wish to take estrogens, non-hormonal management is now a realistic option.

Keywords: Behavioral therapies; Gabapentin; Menopause; Non-hormonal management; Selective serotonin-reuptake inhibitors; Vasomotor symptoms.

Publication types

  • Consensus Development Conference
  • Review

MeSH terms

  • Amines / therapeutic use
  • Behavior Therapy
  • Calcium Channel Blockers / therapeutic use
  • Complementary Therapies
  • Cyclohexanecarboxylic Acids / therapeutic use
  • Diet
  • Exercise
  • Female
  • Gabapentin
  • Hot Flashes / therapy*
  • Humans
  • Life Style
  • Menopause / drug effects
  • Menopause / physiology*
  • Middle Aged
  • Selective Serotonin Reuptake Inhibitors / therapeutic use
  • Sweating*
  • gamma-Aminobutyric Acid / therapeutic use


  • Amines
  • Calcium Channel Blockers
  • Cyclohexanecarboxylic Acids
  • Serotonin Uptake Inhibitors
  • gamma-Aminobutyric Acid
  • Gabapentin