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. 2015 May 13;12(5):5116-28.
doi: 10.3390/ijerph120505116.

Exposure Monitoring and Risk Assessment of Biphenyl in the Workplace

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Free PMC article

Exposure Monitoring and Risk Assessment of Biphenyl in the Workplace

Hyeon-Yeong Kim et al. Int J Environ Res Public Health. .
Free PMC article

Abstract

This study was performed to assess exposure to and the risk caused by biphenyl in the workplace. Biphenyl is widely used as a heat transfer medium and as an emulsifier and polish in industry. Vapor or high levels of dust inhalation and dermal exposure to biphenyl can cause eye inflammation, irritation of respiratory organs, and permanent lesions in the liver and nervous system. In this study, the workplace environment concentrations were assessed as central tendency exposure and reasonable maximum exposure and were shown to be 0.03 and 0.12 mg/m³, respectively. In addition, the carcinogenic risk of biphenyl as determined by risk assessment was 0.14 × 10⁻⁴ (central tendency exposure) and 0.56 × 10⁻⁴ (reasonable maximum exposure), which is below the acceptable risk value of 1.0 × 10⁻⁴. Furthermore, the central tendency exposure and reasonable maximum exposure hazard quotients were 0.01 and 0.06 for oral toxicity, 0.05 and 0.23 for inhalation toxicity, and 0.08 and 0.39 for reproduction toxicity, respectively, which are all lower than the acceptable hazard quotient of 1.0. Therefore, exposure to biphenyl was found to be safe in current workplace environments. Because occupational exposure limits are based on socioeconomic assessment, they are generally higher than true values seen in toxicity experiments. Based on the results of exposure monitoring of biphenyl, the current occupational exposure limits in Korea could be reviewed.

Keywords: biphenyl; carcinogen; exposure; industrial; response; toxicity.

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References

    1. American Conference of Governmental Industrial Hygienists . Documentation of Threshold Limit Values for Chemical Substances and Physical Agents and Biological Exposure Indices. American Conference of Governmental Industrial Hygienists; Cincinnati, OH, USA: 2005.
    1. Hazardous Substances Data Bank . Biphenyl CasRN: 92-52-4. U.S. National Library of Medicine; Bethesda, MA, USA: 2005.
    1. Khera K.S., Whalen C., Angers G., Trivett G. Assessment of the teratogenic potential of piperonyl butoxide, biphenyl, and phosalone in the rat. Toxicol. Appl. Pharmacol. 1979;47:353–358. doi: 10.1016/0041-008X(79)90330-2. - DOI - PubMed
    1. Umeda Y., Aiso S., Yamazaki K., Ohnishi M., Arito H., Nagano K., Yamamoto S., Matsushima T. Carcinogenicity of biphenyl in mice by two years feeding. J. Veter. Med. Sci. 2005;67:417–424. doi: 10.1292/jvms.67.417. - DOI - PubMed
    1. Umeda Y., Arito H., Kano H., Ohnishi M., Matsumoto M., Nagano K., Yamamoto S., Matsushima T. Two-year study of carcinogenicity and chronic toxicity of biphenyl in rats. J. Occup. Health. 2002;44:176–183. doi: 10.1539/joh.44.176. - DOI

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