Vaccine coverage in CF children: A French multicenter study

J Cyst Fibros. 2015 Sep;14(5):615-20. doi: 10.1016/j.jcf.2015.04.006. Epub 2015 May 16.


Backgrounds: Recent reports have pointed the low vaccine coverage in patients with chronic diseases. Data are lacking in patients with cystic fibrosis (CF). Gaining more information on coverage both for mandatory vaccines and those more specifically recommended would help to optimize care of these patients.

Methods: Data were extracted from the "MucoFlu" study, which was a prospective study performed in 2009 in the 5 cystic fibrosis centers of the Paris metropolitan area. Data on mandatory and recommended vaccines in CF were collected in the health booklet and compared to the coverage of the general population.

Results: A total of 134 CF children were included. Vaccination coverage for mandatory vaccines was insufficient (DTPCaHi, conjugate pneumococcal, BCG, MMR and hepatitis B) at 1year of age with no catching-up with age in contrast to the general population. Approximately 66% of the children had immunization for seasonal influenza and 91% for 2009 pandemic flu. Coverage for vaccines specifically recommended in CF was low for hepatitis A, non conjugate pneumococcal and varicella.

Conclusion: This study shows a defect in vaccine coverage for both routine immunization and vaccines more specifically recommended in CF.

Keywords: Cystic fibrosis; Hepatitis B; Immunization; Influenza; Vaccine coverage.

Publication types

  • Clinical Trial
  • Multicenter Study

MeSH terms

  • Adolescent
  • Child
  • Child, Preschool
  • Cystic Fibrosis / complications
  • Cystic Fibrosis / epidemiology
  • Cystic Fibrosis / therapy*
  • Female
  • France / epidemiology
  • Humans
  • Incidence
  • Infant
  • Male
  • Prospective Studies
  • Vaccination / statistics & numerical data*
  • Viral Vaccines / pharmacology*
  • Virus Diseases / complications
  • Virus Diseases / epidemiology
  • Virus Diseases / prevention & control*


  • Viral Vaccines