Safety of Radioembolization with (90)Yttrium Resin Microspheres Depending on Coiling or No-Coiling of Aberrant/High-Risk Vessels

Cardiovasc Intervent Radiol. 2015 Aug;38(4):946-56. doi: 10.1007/s00270-015-1128-x. Epub 2015 May 20.


Purpose: To evaluate the safety of radioembolization (RE) with (90)Yttrium ((90)Y) resin microspheres depending on coiling or no-coiling of aberrant/high-risk vessels.

Materials and methods: Early and late toxicity after 566 RE procedures were analyzed retrospectively in accordance with the National Cancer Institute's Common Terminology Criteria for Adverse Events (CTCAE v3.0). For optimal safety, aberrant vessels were either coil embolized (n = 240/566, coiling group) or a more peripheral position of the catheter tip was chosen to treat right or left liver lobes (n = 326/566, no-coiling group).

Results: Clinically relevant late toxicities (≥ Grade 3) were observed in 1% of our overall cohort. The no-coiling group had significantly less "any" (P = 0.0001) or "clinically relevant" (P = 0.0003) early toxicity. There was no significant difference (P > 0.05) in delayed toxicity in the coiling versus the no-coiling group. No RE-induced liver disease was noted after all 566 procedures.

Conclusion: RE with (90)Y resin microspheres is a safe and effective treatment option. Performing RE without coil embolization of aberrant vessels prior to treatment could be an alternative for experienced centers.

MeSH terms

  • Brachytherapy / adverse effects*
  • Embolization, Therapeutic / methods*
  • Humans
  • Liver / radiation effects
  • Liver Neoplasms / radiotherapy*
  • Microspheres
  • Retrospective Studies
  • Treatment Outcome
  • Yttrium Radioisotopes / therapeutic use*


  • Yttrium Radioisotopes