Prospective multicenter international surveillance of azole resistance in Aspergillus fumigatus

Emerg Infect Dis. 2015 Jun;21(6):1041-4. doi: 10.3201/eid2106.140717.


To investigate azole resistance in clinical Aspergillus isolates, we conducted prospective multicenter international surveillance. A total of 3,788 Aspergillus isolates were screened in 22 centers from 19 countries. Azole-resistant A. fumigatus was more frequently found (3.2% prevalence) than previously acknowledged, causing resistant invasive and noninvasive aspergillosis and severely compromising clinical use of azoles.

Keywords: Aspergillus; antimicrobial resistance; aspergillosis; azole resistance; fungi; international; prevalence; surveillance.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antifungal Agents / pharmacology*
  • Aspergillosis / epidemiology*
  • Aspergillosis / microbiology*
  • Aspergillus fumigatus / drug effects*
  • Aspergillus fumigatus / genetics
  • Azoles / pharmacology*
  • Drug Resistance, Fungal*
  • Humans
  • Microbial Sensitivity Tests
  • Mutation
  • Population Surveillance*
  • Prevalence
  • Prospective Studies


  • Antifungal Agents
  • Azoles