Orthobunyavirus antibodies among humans in selected parts of the Rift Valley and northeastern Kenya

doi:10.1089/vbz.2014.1760

. 2015 May;15(5):329-32.

doi: 10.1089/vbz.2014.1760.

Orthobunyavirus antibodies among humans in selected parts of the Rift Valley and northeastern Kenya

Collins Odhiambo^{1

2

3}, Marietjie Venter^{2

4}, Robert Swanepoel², Rosemary Sang^{1

3}

Affiliations

¹ 1Human Health Division, International Centre of Insect Physiology and Ecology, Nairobi, Kenya.
² 2Zoonoses Research Unit, Department Medical Virology, University of Pretoria, Pretoria, South Africa.
³ 3Centre for Virus Research, Department of Medical Virology, Kenya Medical Research Institute, Nairobi, Kenya.
⁴ 4Global Disease Detection, US Centers for Disease Control and Prevention, Pretoria, South Africa.

PMID: 25988444
PMCID: PMC4666525
DOI: 10.1089/vbz.2014.1760

Orthobunyavirus antibodies among humans in selected parts of the Rift Valley and northeastern Kenya

Collins Odhiambo et al. Vector Borne Zoonotic Dis. 2015 May.

. 2015 May;15(5):329-32.

doi: 10.1089/vbz.2014.1760.

Authors

Collins Odhiambo^{1

2

3}, Marietjie Venter^{2

4}, Robert Swanepoel², Rosemary Sang^{1

3}

Affiliations

¹ 1Human Health Division, International Centre of Insect Physiology and Ecology, Nairobi, Kenya.
² 2Zoonoses Research Unit, Department Medical Virology, University of Pretoria, Pretoria, South Africa.
³ 3Centre for Virus Research, Department of Medical Virology, Kenya Medical Research Institute, Nairobi, Kenya.
⁴ 4Global Disease Detection, US Centers for Disease Control and Prevention, Pretoria, South Africa.

PMID: 25988444
PMCID: PMC4666525
DOI: 10.1089/vbz.2014.1760

Abstract

Ngari, Bunyamwera, Ilesha, and Germiston viruses are among the mosquito-borne human pathogens in the Orthobunyavirus genus, family Bunyaviridae, associated with febrile illness. Although the four orthobunyaviruses have been isolated from mosquito and/or tick vectors sampled from different geographic regions in Kenya, little is known of human exposure in such areas. We conducted a serologic investigation to determine whether orthobunyaviruses commonly infect humans in Kenya. Orthobunyavirus-specific antibodies were detected by plaque reduction neutralization tests in 89 (25.8%) of 345 persons tested. Multivariable analysis revealed age and residence in northeastern Kenya as risk factors. Implementation of acute febrile illness surveillance in northeastern Kenya will help to detect such infections.

Keywords: Arboviruses; Bunyaviridae; Kenya; Orthobunyavirus.

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Conflict of interest statement

Author Disclosure Statement

No conflicting financial interests exist.

The opinions expressed by authors contributing to this journal do not necessarily reflect the opinions of the Centers for Disease Control and Prevention or the institutions with which the authors are affiliated

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References

1. Blaney JE, Jr, Johnson DH, Firestone CY, Hanson CT, et al. Chemical mutagenesis of dengue virus type 4 yields mutant viruses which are temperature sensitive in Vero cells or human liver cells and attenuated in mice. J Virol. 2001;75:9731–9740. - PMC - PubMed
1. Blitvich BJ, Saiyasombat R, Talavera-Aguilar LG, Garcia-Rejon JE, et al. Orthobunyavirus antibodies in humans, Yucatan Peninsula, Mexico. Emerg Infect Dis. 2012;18:1629–1632. - PMC - PubMed
1. Briese T, Bird B, Kapoor V, Nichol ST, et al. Batai and Ngari viruses: M segment reassortment and association with severe febrile disease outbreaks in East Africa. J Virol. 2006;80:5627–5630. - PMC - PubMed
1. Crabtree M, Sang R, Lutomiah J, Richardson J, et al. Arbovirus surveillance of mosquitoes collected at sites of active Rift Valley Fever virus transmission: Kenya, 2006–2007. J Med Entomol. 2009;46:961–964. - PubMed
1. Gerrard SR, Li L, Barrett AD, Nichol ST. Ngari virus is a Bunyamwera virus reassortant that can be associated with large outbreaks of hemorrhagic fever in Africa. J Virol. 2004;78:8922–8926. - PMC - PubMed

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[1] Blaney JE, Jr, Johnson DH, Firestone CY, Hanson CT, et al. Chemical mutagenesis of dengue virus type 4 yields mutant viruses which are temperature sensitive in Vero cells or human liver cells and attenuated in mice. J Virol. 2001;75:9731–9740. - PMC - PubMed

[2] Blaney JE, Jr, Johnson DH, Firestone CY, Hanson CT, et al. Chemical mutagenesis of dengue virus type 4 yields mutant viruses which are temperature sensitive in Vero cells or human liver cells and attenuated in mice. J Virol. 2001;75:9731–9740. - PMC - PubMed

[3] Blitvich BJ, Saiyasombat R, Talavera-Aguilar LG, Garcia-Rejon JE, et al. Orthobunyavirus antibodies in humans, Yucatan Peninsula, Mexico. Emerg Infect Dis. 2012;18:1629–1632. - PMC - PubMed

[4] Blitvich BJ, Saiyasombat R, Talavera-Aguilar LG, Garcia-Rejon JE, et al. Orthobunyavirus antibodies in humans, Yucatan Peninsula, Mexico. Emerg Infect Dis. 2012;18:1629–1632. - PMC - PubMed

[5] Briese T, Bird B, Kapoor V, Nichol ST, et al. Batai and Ngari viruses: M segment reassortment and association with severe febrile disease outbreaks in East Africa. J Virol. 2006;80:5627–5630. - PMC - PubMed

[6] Briese T, Bird B, Kapoor V, Nichol ST, et al. Batai and Ngari viruses: M segment reassortment and association with severe febrile disease outbreaks in East Africa. J Virol. 2006;80:5627–5630. - PMC - PubMed

[7] Crabtree M, Sang R, Lutomiah J, Richardson J, et al. Arbovirus surveillance of mosquitoes collected at sites of active Rift Valley Fever virus transmission: Kenya, 2006–2007. J Med Entomol. 2009;46:961–964. - PubMed

[8] Crabtree M, Sang R, Lutomiah J, Richardson J, et al. Arbovirus surveillance of mosquitoes collected at sites of active Rift Valley Fever virus transmission: Kenya, 2006–2007. J Med Entomol. 2009;46:961–964. - PubMed

[9] Gerrard SR, Li L, Barrett AD, Nichol ST. Ngari virus is a Bunyamwera virus reassortant that can be associated with large outbreaks of hemorrhagic fever in Africa. J Virol. 2004;78:8922–8926. - PMC - PubMed

[10] Gerrard SR, Li L, Barrett AD, Nichol ST. Ngari virus is a Bunyamwera virus reassortant that can be associated with large outbreaks of hemorrhagic fever in Africa. J Virol. 2004;78:8922–8926. - PMC - PubMed

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Orthobunyavirus antibodies among humans in selected parts of the Rift Valley and northeastern Kenya

Affiliations

Orthobunyavirus antibodies among humans in selected parts of the Rift Valley and northeastern Kenya

Authors

Affiliations

Abstract

Conflict of interest statement

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References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

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Medical