Genetics: dynamic cellular aging markers associated with major depression

Curr Biol. 2015 May 18;25(10):R409-11. doi: 10.1016/j.cub.2015.03.036.


Psychiatric diseases are associated with an increased rate of somatic age-related illness. A new study sheds light on putative mediating cellular mechanisms by linking increased mitochondrial DNA copy number and decreased telomere length to childhood stress and major depression.

Publication types

  • Comment

MeSH terms

  • Animals
  • DNA, Mitochondrial / metabolism*
  • Depressive Disorder, Major / metabolism*
  • Female
  • Humans
  • Male
  • Stress, Psychological / metabolism*
  • Telomere Shortening*


  • DNA, Mitochondrial