Tumor Metabolism: MAGE-A Proteins Help TRIM Turn Over AMPK

Curr Biol. 2015 May 18;25(10):R418-20. doi: 10.1016/j.cub.2015.03.019.

Abstract

MAGE-A proteins are testis-specific E3 ubiquitin ligase components whose expression is upregulated in many cancers. MAGE-A3 and -A6 act as oncogenes and recent work now shows that they degrade the central metabolic regulator AMPK, providing a novel mechanism for rewiring cancer metabolism.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • AMP-Activated Protein Kinases / metabolism*
  • Animals
  • Antigens, Neoplasm / metabolism*
  • Male
  • Neoplasm Proteins / metabolism*
  • Neoplasms / metabolism*

Substances

  • Antigens, Neoplasm
  • Neoplasm Proteins
  • AMP-Activated Protein Kinases