Emerging role of long noncoding RNAs in autoimmune diseases

Autoimmun Rev. 2015 Sep;14(9):798-805. doi: 10.1016/j.autrev.2015.05.004. Epub 2015 May 16.


Long noncoding RNA (lncRNA), with size larger than 200 nucleotides, is a new class of noncoding RNA. Emerging evidence has revealed that lncRNAs play a key role in the regulation of immunological functions and autoimmunity. Herein, we review the recent findings of lncRNA regulation in immune functions and in the development of autoimmunity and autoimmune disease. In addition, we focus on the involvement of lncRNA regulation in innate and adaptive immune responses, immune cell development, and differential expression of lncRNAs in autoimmune diseases, including systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), type 1 diabetes mellitus (T1DM), multiple sclerosis (MS), autoimmune thyroid disease (AITD), psoriasis, polymyositis/dermatomyositis (PM/DM) and Crohn's disease (CD).

Keywords: Autoimmune disease; Autoimmunity; Immune function; Noncoding RNA; lncRNA.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Autoimmune Diseases / genetics*
  • Autoimmune Diseases / immunology*
  • Autoimmunity / immunology
  • Humans
  • Psoriasis / genetics
  • Psoriasis / immunology
  • RNA, Long Noncoding / genetics*
  • Thyroid Diseases / genetics
  • Thyroid Diseases / immunology
  • Toll-Like Receptors / immunology


  • RNA, Long Noncoding
  • Toll-Like Receptors