Design of ultrasensitive DNA-based fluorescent pH sensitive nanodevices

Nanoscale. 2015 Jun 14;7(22):10008-12. doi: 10.1039/c5nr01158b. Epub 2015 May 20.


Here we tune the pH sensitivity of a DNA-based conformational switch, called the I-switch, to yield a set of fluorescent pH sensitive nanodevices with a collective, expanded pH sensing regime from 5.3 to 7.5. The expanded pH regime of this new family of I-switches originates from a dramatic improvement in the overall percentage signal change in response to pH of these nanodevices.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biosensing Techniques / instrumentation
  • Biosensing Techniques / methods*
  • DNA / chemistry*
  • Fluorescent Dyes / chemistry
  • Hydrogen-Ion Concentration
  • Nanostructures / chemistry*
  • Nanotechnology / instrumentation
  • Nanotechnology / methods*
  • Sensitivity and Specificity


  • Fluorescent Dyes
  • DNA