DSigDB: drug signatures database for gene set analysis

Bioinformatics. 2015 Sep 15;31(18):3069-71. doi: 10.1093/bioinformatics/btv313. Epub 2015 May 19.


We report the creation of Drug Signatures Database (DSigDB), a new gene set resource that relates drugs/compounds and their target genes, for gene set enrichment analysis (GSEA). DSigDB currently holds 22 527 gene sets, consists of 17 389 unique compounds covering 19 531 genes. We also developed an online DSigDB resource that allows users to search, view and download drugs/compounds and gene sets. DSigDB gene sets provide seamless integration to GSEA software for linking gene expressions with drugs/compounds for drug repurposing and translational research.

Availability and implementation: DSigDB is freely available for non-commercial use at http://tanlab.ucdenver.edu/DSigDB.

Supplementary information: Supplementary data are available at Bioinformatics online.

Contact: aikchoon.tan@ucdenver.edu.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carcinoma, Non-Small-Cell Lung / drug therapy
  • Carcinoma, Non-Small-Cell Lung / genetics
  • Computational Biology / methods*
  • Databases, Pharmaceutical*
  • Drug Repositioning
  • ErbB Receptors / antagonists & inhibitors
  • ErbB Receptors / genetics
  • Gene Expression Profiling*
  • Gene Expression Regulation*
  • Humans
  • Lung Neoplasms / drug therapy
  • Lung Neoplasms / genetics*
  • Mutation / genetics
  • Protein Kinase Inhibitors / pharmacology*
  • Software*


  • Protein Kinase Inhibitors
  • EGFR protein, human
  • ErbB Receptors