Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 7, 45

Shift Work and Its Association With Metabolic Disorders


Shift Work and Its Association With Metabolic Disorders

Maria Carlota Borba Brum et al. Diabetol Metab Syndr.


Although the health burden of shift work has not been extensively studied, evidence suggests that it may affect the metabolic balance and cause obesity and other metabolic disorders. Sleep deprivation, circadian desynchronization and behavioral changes in diet and physical activity are among the most commonly mentioned factors in studies of the association between night work and metabolic disorders. Individual adaptation to night work depends greatly on personal factors such as family and social life, but occupational interventions may also make a positive contribution to the transition to shift work, such as exposure to bright lights during the night shift, melatonin use, shift regularity and clockwise rotation, and dietary adaptations for the metabolic needs of night workers. The evaluation of the impact of night work on health and of the mechanisms underlying this relationship can serve as a basis for intervention strategies to minimize the health burden of shift work. This review aimed to identify highlights regarding therapeutic implications following the association between night and shift work and metabolic disorders, as well as the mechanisms and pathways responsible for these relationships.

Keywords: Diabetes; Hypertension; Insulin resistance; Metabolic syndrome; Obesity; Shift work; Sleep restriction.

Similar articles

See all similar articles

Cited by 28 articles

See all "Cited by" articles


    1. de C Moreno CR, Fischer FM, Rotenberg L. A saúde do trabalhador na sociedade 24 horas. São Paulo Em Perspect. 2003;17:34–46. doi: 10.1590/S0102-88392003000100005. - DOI
    1. Organização Internacional do Trabalho: Convenção sobre Trabalho Noturno–C171, 1990, Genebra.
    1. Rodrigues VP. Principais impactos do trabalho em turnos: estudo de caso de uma sonda de perfuração marítima. R Un Alfenas. 1998;4:199–207.
    1. Burchell B. European foundation for the improvement of living and working conditions. Working conditions in the European union: working time and work intensity. Luxembourg: Office for Official Publications of the European Communities; 2009.
    1. Karlsson B. Is there an association between shift work and having a metabolic syndrome? results from a population based study of 27 485 people. Occup Environ Med. 2001;58:747–52. doi: 10.1136/oem.58.11.747. - DOI - PMC - PubMed

LinkOut - more resources