Non-steroidal anti-inflammatory drugs and their benefits and harms: the challenge of interpreting meta-analyses and observational data sets when balanced data are not analyzed and reported

Arthritis Res Ther. 2015 May 21;17(1):130. doi: 10.1186/s13075-015-0650-1.

Abstract

A multitude of reports have delineated the risks of using non-steroidal anti-inflammatory drugs but have not been totally congruent. Meta-analyses of randomized controlled trials sometimes concur regarding gastrointestinal risk and cardiovascular risk but rarely report a balance of these risks for any one drug. Benefits measured in these studies are usually not reported. Observational data sets, supposedly reflective of 'real world' patients, do not always agree with the randomized controlled trial reports. Clinicians need assessments measuring the balance of harms and benefits so that better decisions based on their patients' unique risk factors can be reached.

Publication types

  • Editorial

MeSH terms

  • Anti-Inflammatory Agents, Non-Steroidal / adverse effects*
  • Humans
  • Meta-Analysis as Topic*
  • Observational Studies as Topic*

Substances

  • Anti-Inflammatory Agents, Non-Steroidal