Kaempferia parviflora extract increases whole-body energy expenditure in humans: roles of brown adipose tissue

J Nutr Sci Vitaminol (Tokyo). 2015;61(1):79-83. doi: 10.3177/jnsv.61.79.


Kaempferia parviflora extract (KP) has been reported to have a preventive effect on obesity in mice, probably by increasing energy expenditure (EE). The aims of the current study were to examine the acute effects of KP ingestion on whole-body EE in humans and to analyze its relation to the activity of brown adipose tissue (BAT), a site of non-shivering thermogenesis. After an oral ingestion of an ethanol extract of KP, EE increased significantly, showing a maximal increase of 229±69 kJ/d at 60 min, while it did not change after placebo ingestion. To evaluate BAT activity, the subjects underwent fluorodeoxyglucose-positron emission tomography, and divided into two groups with high- and low-BAT activities. A similar and greater response of EE to KP ingestion was observed in the high-BAT group (351±50 kJ/d at 60 min), but not in the low activity group. Placebo ingestion did not cause any significant EE change in either group. These results indicate that a single oral ingestion of the KP extract can potentially increase whole-body EE probably through the activation of BAT in healthy men, and may be useful as an anti-obesity regimen.

Publication types

  • Clinical Trial

MeSH terms

  • Adipose Tissue, Brown / drug effects*
  • Adipose Tissue, Brown / metabolism
  • Adult
  • Energy Metabolism / drug effects*
  • Humans
  • Male
  • Obesity / metabolism*
  • Obesity / prevention & control
  • Phytotherapy
  • Plant Extracts / pharmacology*
  • Plant Extracts / therapeutic use
  • Positron-Emission Tomography / methods
  • Thermogenesis / drug effects*
  • Young Adult
  • Zingiberaceae*


  • Plant Extracts